Opiates, the Pylorus, and Gastroparesis

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The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus.

OBJECTIVE Gastroparesis is a disorder of delayed gastric emptying that is often chronic in nature. Up to 50% of type 1 diabetic subjects have symptoms of gastroparesis, which include nausea, vomiting, and early satiety. Elevated pyloric pressures may be responsible for delayed gastric emptying in diabetic subjects. Botulinum toxin inhibits the release of acetylcholine and produces transient par...

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Prevalence of Hidden Gastroparesis in the Community: The Gastroparesis "Iceberg"

BACKGROUND/AIMS The prevalence of diagnosed gastroparesis is 24.2/100,000 inhabitants, but a large group of people with gastroparesis-like symptoms have never had a gastric emptying (GE) test. Some of them may have undiagnosed gastroparesis. Our aim was to estimate the prevalence of hidden gastroparesis in the community. METHODS The study was conducted in 2 parts: (1) Patients referred for a ...

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The GI Surgeon and Gastroparesis

54 OVERVIEWS OF GASTROPARESIS Gastroparesis is characterized by delayed or impaired passage of gastric contents in the absence of mechanical obstruction. Symptoms vary and include nausea, vomiting, bloating, and abdominal pain. The symptoms and clinical presentation of gastroparesis is reflective of its pathogenesis, severity, and association with predisposing or associated conditions. Gastropa...

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Opiates and plasticity.

Opiates are among the most powerful analgesics and pain-relieving agents. However, they are potentially extremely addictive thereby limiting their medical use, making them exceedingly susceptible to abuse and adding to the global drug problem. It is believed that positive memories associated with the pleasurable effects of opiates and negative memories associated with dysphoria during opiate wi...

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Adenomyoma in the pylorus.

CASE 1 A 27-year-old man had epigastric pain, relieved by antacids, occurring two hours after meals, for three years. A clinical diagnosis of peptic ulcer was made. At laparotomy a hard white thickening of the pylorus was found. Partial gastrectomy with closure of the duodenal stump and anastomosis of the stomach and jejunum was performed. Naked-eye examination revealed a localized thickening u...

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ژورنال

عنوان ژورنال: Gastroenterology

سال: 2020

ISSN: 0016-5085

DOI: 10.1053/j.gastro.2020.04.072